desmethylanethol trithione Property

Melting point:

191-192 °C

Boiling point:

431.4±55.0 °C(Predicted)

Density 

1.56±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

DMF: 15 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 5 mg/ml; Ethanol: 1 mg/ml

form 

A crystalline solid

pka

9.78±0.30(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

desmethylanethol trithione Chemical Properties,Usage,Production

Description

ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H₂S) donor. It can be readily esterified with other moieties. For example, it can be coupled with therapeutics like nonsteroidal anti-inflammatory drugs, as in the generation of ATB-343 . ADT-OH has also been linked with a mitochondria-targeting motif to produce AP-39 , which selectively increases mitochondrial H₂S levels. ADT-OH is used both in cells and in animals for comparative studies with derived chimeras.

Uses

is used in method for preventing or treating diseases associated with administration of VEGFR and/or VEGF inhibitor.